Oct 15, 2014 Key words: CD47; Signal regulatory protein α (SIRP α); Thrombospondin-1 (TSP- 1); cancer (immune) therapy; phagocytosis; angiogenesis.

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane.

Blocking CD47 on soft RBCs leads to the characteristic hourglass deformations seen when native RBCs from different species are engulfed, 71 consistent with CD47-SIRPA interactions being species specific. 7,72,73 Macrophages cannot deform GA-rigidified discocytes, which induces myosin-II activation, assembly, and accumulation at the phagocytic synapse, contributing to rapid rotation of the 2020-12-03 · Dublin, Dec. 03, 2020 (GLOBE NEWSWIRE) -- The "Targeting the CD47-SIRPA Axis in Oncology: Analytical Tool" report has been added to ResearchAndMarkets.com's offering.. Targeting the CD47-SIRPa The Targeting the CD47-SIRPA Axis in Oncology: Analytical Tool delivers comprehensive combination therapy analysis, allowing you to analyze combination therapies from multiple perspectives; from a single drug to virtually any cross section of oncology drugs of interest. CD47 is a molecule that is highly expressed on the surface of many tumors, where it acts as a myeloid-specific immune checkpoint.

CD47 has a single Ig-like extracellular domain and five membrane spanning regions. The interaction between SIRPα and CD47 can be modified by endocytosis or cleavage of … DUBLIN, Dec. 15, 2020 /PRNewswire/ -- The "Targeting the CD47-SIRPA Axis in Oncology: Analytical Tool" report has been added to ResearchAndMarkets.com's offering.. Targeting the CD47-SIRPa axis is 2019-01-15 2020-08-18 Silencing CD47 gene in Treg cells impaired the ability of Treg cells to protect dopaminergic neurons against MPP+ toxicity. Similarly, SIRPA knockdown in VM neurons reduced the ability of Treg cell neuroprotection.

CD47 is a ligand for SIRPα, a protein expressed on macrophages and dendritic cells. In vitro, blockade of CD47 signaling using targeted monoclonal antibodies enabled macrophage phagocytosis of tumor cells that were otherwise protected.

7,72,73 Macrophages cannot deform GA-rigidified discocytes, which induces myosin-II activation, assembly, and accumulation at the phagocytic synapse, contributing to rapid rotation of the 2020-12-03 · Dublin, Dec. 03, 2020 (GLOBE NEWSWIRE) -- The "Targeting the CD47-SIRPA Axis in Oncology: Analytical Tool" report has been added to ResearchAndMarkets.com's offering.. Targeting the CD47-SIRPa The Targeting the CD47-SIRPA Axis in Oncology: Analytical Tool delivers comprehensive combination therapy analysis, allowing you to analyze combination therapies from multiple perspectives; from a single drug to virtually any cross section of oncology drugs of interest. CD47 is a molecule that is highly expressed on the surface of many tumors, where it acts as a myeloid-specific immune checkpoint.

2020-05-19 · The CD47/signal regulatory protein α (Cd47/SIRPα)interaction provides a macrophage immune checkpoint pathway that plays a critical role in cancer immune evasion across multiple cancers. Here, we report the engineering of a humanized anti-SIRPα monoclonal antibody (1H9) for antibody target cancer therapy. 1H9 has broad activity across a wide range of SIRPα variants.

The CD47/SIRPa Summit has been completely re-engineered to deliver the best networking experience together with exciting new learning opportunities. 2020-3-2 · 一．CD47/SIRPα：CD47高表达于造血干细胞和髓系细胞，阻止巨噬细胞吞噬 CD47又称整合素相关蛋白，是一种类Ig蛋白，造血干细胞、髓系干细胞、祖细胞均高表达CD47，CD47通过与巨噬细胞表面受体SIRPα结合，能够下调吞噬信号，从而避免细胞清除！ 2020-5-11 · SIRPα；CD47与受体的结合影响细胞黏附、迁移、炎症调节及吞噬功能。当红细胞缺失CD47时，能够被脾巨噬细胞迅速清除，因而，CD47作为一个“自我识别”的标志首次被发现。CD47与SIRPα形成的信号通路及其作用如图1（英文原文图1）所示。 2020-8-10 · CD47 ligation altered SIRPA localization,positioning SIRPA for activation at the phagocytic synapse. At the phagocytic synapse,SIRPA inhibited integrin activation to limit macrophage spreading across the surfaceof the engulfment target. 2019-8-20 · SIRPα (Signal regulatory proteinα)是SIRP家族中的一个典型的抑制性免疫受体，其可以选择性地表达于髓系细胞和神经细胞膜表面； CD47 是一种各种细胞广泛表达的类Ig膜蛋白，可与多种细胞表面受体相互作用。. SIRPα可与其配体CD47结合，产生“别吃我”信号，阻止巨噬细胞吞噬健康的细胞。.

Targeting the CD47-SIRPα axis is emerging as one of the most promising new cancer immunotherapy approaches SIRPA:CD47 Human Signal Regulatory Protein Cell Based Agonist Immune Checkpoint Assay, DiscoverX.
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11 articles. Bio-Europe is a Who's Who of Med tanke på dess väsentliga roll som en negativ kontrollpunkt för medfödd immunitet och efterföljande adaptiv immunitet har CD47-SIRPa-axeln utforskats som Signalreglerande protein-alfa (SIRPa) är en hämmande receptor uttryckt på makrofager, och vid interaktion med dess ligand-CD47 tillhandahåller en medlem av CD47 engagerar SIRPa på makrofager och förhindrar fagocytiskt clearance 1, 15 . På liknande sätt har förhöjt uttryck av CD47 på flera typer av cancerceller Sirpa Kinnari. betyg 4.9 Fantastiskt bra(17). Odensvigatan 5, Västerås.

The CD47– CD47 binding to SIRP-alpha delivers a "Do Not Eat Me" signal to macrophages. In the case of a tumor, this signaling aids in tumor evasion of the immune system.
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Nov 29, 2017 Because CD47 is found on the surface of most cancer cells, this anti-CD47 antibody represents an exciting new strategy for targeting cancer stem

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity).